(A) The de novo inactivation model requires many rounds of inactivation and reactivation: the paternal germline initiates meiotic sex-chromosome inactivation, but the X chromosome is completely ...

Eighty percent of patients with autoimmune diseases are female. These diseases are one of the top 10 leading causes of death for women under 65, and cases are increasing annually worldwide. There is ...

Cancer cells acquire genetic changes that allow them to grow and proliferate unchecked. Researchers at the Dana-Faber Cancer Institute and colleagues have now found another difference between cancer ...

X-chromosome inactivation varies across different areas of brains. Here, fluorescent imaging data from a mouse reveal where the father’s X chromosome is most active (white) and least active (blue). A ...

All female mammals, including humans, have two X chromosomes. Normal development requires one X chromosome to be inactivated. A balance of protein clusters called cohesins is needed to alter X ...

Female mammals have a higher risk of developing autoimmune conditions such as lupus because extra copies of genes that are supposed to be permanently turned off get reactivated as they grow older, a ...

Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg and Institut Curie in Paris have shown that the protein SPEN plays a crucial role in the process of X-chromosome ...

In most mammals, females have two X chromosomes and males have one X and one Y chromosome in each of their cells. To avoid a double dose of X-linked genes in females, one of the Xs is silenced early ...

Researchers at Massachusetts General Hospital (MGH) have identified a key mechanism in X chromosome inactivation, a phenomenon that may hold clues that lead to treatments for certain rare congenital ...

The eed (embryonic ectoderm development) gene is a member of the mouse Polycomb group (Pc-G) and is required for early gastrulation. In the Advance Online issue of Nature Genetics, Jianbo Wang and ...

Researchers at Linköping University in Sweden made an unexpected discovery while investigating genetically unique women. Their insights advance our understanding of our most enigmatic chromosome, the ...

a | The de novo inactivation model requires many rounds of inactivation and reactivation: the paternal germline initiates meiotic sex-chromosome inactivation, but the X chromosome is completely ...