In human cells, lengthy strands of DNA have to be carefully organized and compacted so they'll fit into the nucleus; our genome is arranged into chromosomes that have to be duplicated each time a cell ...

Cells have to maintain the proper number of chromosomes or serious disease can result. In humans, cells each have 23 pairs and when they divide, it’s critical to ...

Here, we discuss the recently proposed oncogene-induced mitotic stress model that provides a mechanistic framework for the long-standing paradox that the majority of cancers are aneuploid, whereas ...

During the development of gametes, such as egg and sperm cells in humans, chromosomes are broken and rearranged at many positions. Using state of the art technology, researchers in Austria have ...

Researchers from the University of Tennessee Health Science Center have made a foundational discovery about chromosome biology through their work on the first-ever human pangenome reference. Published ...

Once in every cell cycle microtubules become organized into a bipolar spindle that segregates the replicated chromosomes to the two daughter cells 1,2. Two models, which are not mutually exclusive, ...

In a biological first, an international team has inserted a man-made chromosome into brewer's yeast, producing a life form that thrives and successfully passes the designer genes on to its offspring.

Highly challenging to sequence and long overlooked, the human Y chromosome's contributions to health and disease remain largely unknown. A new paper that presents, for the first time, the complete ...